CINGAL demonstrated a very strong safety profile in its clinical study. Avoid Cingal if you: CINGAL 13-02, an open-label, follow-on study to Cingal 13-01. DUROLANE is a single injection treatment to relieve the pain of osteoarthritis (OA) in specific small and large joints.2 It is based upon a natural, safe and proven technology called NASHA®. Talk to your doctor if you have questions regarding these products, or for more information on pain associated with osteoarthritis of … The injection of Cingal® supplements (adds) hyaluronic acid into the knee joint. In a CINGAL clinical study, a low number of patients experienced minor side effects. Cingal®, Monovisc®, and Orthovisc® may not be suitable for everyone. Local of molecular office. Read the entire detailed patient monograph for Aristospan Injection 20 (Triamcinolone Hexacetonide Injectable Suspension) The safety and effectiveness of Cingal® have not been shown in pregnant or nursing women. In addition, both HA viscosupplements and corticosteroids are individually well established with proven track records supporting their safety and performance in the treatment of the pain of osteoarthritis.1,2. A single injection of Cingal® or Monovisc®, or three injections of Orthovisc®, can help alleviate pain caused by osteoarthritis of the knee for up to 6 months. *Significant reduction in pain measures seen at Week 1 vs. saline (ITT p=0.008). Cingal® is a proud partner of the 2019 Rogers Cup in Montreal. Medical and Scientific Information Services. Mode d’emploi Ce médicament est généralement administré dans un établissement de santé, par un membre du personnel médical. The hyaluronan is highly purified and made from bacterial fermentation. CINGAL is a simple injection that may be done in the convenience of a clinician’s office. Do not administer Cingal to patients with known allergy to hexacetonide preparations or hyaluronate preparations; What are the most common side effects? You may experience facial flushing. Cingal®, Monovisc®, and Orthovisc® may not be suitable for everyone. Appendix II of the device dossier. In addition to providing quick relief, the injection does not cause many of the side effects that oral corticosteroid medications do. You may also feel achy. © 2021 Anika Therapeutics, Inc. All rights reserved. For some, pain relief happens almost immediately, while it may take a few days for others. 1998 Aug 1;58(2):443-450. Hyaluronic acid is a naturally occurring substance found in the synovial fluid of the knee joint. Condition or disease Intervention/treatment Phase ; Knee Osteoarthritis: Device: Hyaluronic Acid and TH Device: Hyaluronic Acid Device: Saline: Not Applicable: Study Design. Doctors can administer the injection in their office. An intra-articular injection session of Cingal typically takes about less than an hour to complete. • Injection Site pain (Short term) 2006 Feb;26(4):314-9. If you have any known allergies, you should talk with your healthcare professional to determine if you are able to receive a Cingal injection. Viscosupplementation, or the injection of hyaluronic acid into the joint, is thought to lubricate the cartilage (much as oil lubricates an engine), thereby reducing pain for long-term relief with a delayed onset. Although there were no time points measured after 26 weeks, clinical results show that the effects of CINGAL lasted and appeared to get stronger at 6 months, allowing patients to continue to experience maximum pain relief.5. Anika Therapeutics, Inc.: study sponsor, Dr. Laszlo Hangody: global principal investigator, SynteractHCR: CRO. Product Licences are pertinent to use in Canada. CINGAL is a transparent gel that contains natural, non-animal sourced hyaluronic acid (HA), combined with a corticosteroid. Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Hyaluronan is a natural chemical found in the body. For additional details and information about the product, please refer to the Instructions for Use that are included in the product’s packaging. Corticosteroid injections have been used for over 45 years4 in the treatment of the symptoms of osteoarthritis for their potent anti-inflammatory effects, to reduce pain quickly and allow earlier motion. What is a hyaluronic acid viscosupplement? Corticosteroids are known as medicines in some countries. Yes. In what joints can I get a CINGAL injection? Download the brochures to learn more. Common side effects include swelling, pain, redness, and skin atrophy. The potential side effects of Cingal include arthralgia; local swelling; effusion; stiffness of the knee; arthropathy; injection site pain, edema, bruising, and/or erythema; facial flushing; post-injection flare; and injection site skin atrophy, calcification, or hypopigmentation. Call your doctor for medical advice about side effects. Once the initial effects wear off, patients can return for maintenance treatment sessions. All were common side effects seen with viscosupplement injections, including injection site pain, joint pain, rash, redness or swelling, and all were resolved naturally without treatment. However, possible complications may arise when Cingal® is injected into the knee joint. Ault A. The corticosteroid contained in Cingal® quickly reduces inflammation to provide fast relief, while the hyaluronic acid cushions the knee joint to provide long-lasting relief. 2006 Apr 19;(2):CD005328. Therapeutic Class (Orthopedics): Cingal ® is the only viscosupplement that combines a corticosteroid for fast pain relief with a viscosupplement, a clear gel-like substance containing hyaluronic acid, for sustained osteoarthritis knee pain relief. Access our private insurance coverage guide for reimbursement information on Cingal®. Son utilisation est encadrée par différents protocoles établis par les spécialistes de l'unité de soins. The Cingal 13-01 study objective was to assess the safety and effectiveness of a single injection of Cingal® for relief of joint pain and symptoms in patients with osteoarthritis (OA) of the knee. Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube. CINGAL ® is a simple, physician-administered injection that delivers fast acting and long lasting pain relief for osteoarthritis so patients can once again enjoy daily physical activities with reduced pain.. It is a simple procedure that may be done in a clinician’s office. This is not a complete list of side effects and others may occur. In this article, we examine the pain and other side effects that may occur after a cortisone injection. Complete the checklist to help you quantify your knee pain and discuss it with your doctor. Il produit son plein effet après quelques jours. Diabetics may observe a transient increase in blood sugar. CINGAL is CE mark approved as a viscoelastic supplement or a replacement for synovial fluid in the knee joint. These can include pain, swelling, heat, rash, itching, bruising, and/or redness. CINGAL demonstrated a very good safety profile in its clinical study as a combination HA plus corticosteroid product in the treatment of knee pain due to osteoarthritis. New York Times, 2003 Dec. 4. If oral painkillers and lifestyle changes such as exercising and losing weight are not providing you with adequate pain relief, Cingal® may be a good option to relieve your osteoarthritis knee pain. Side Effects. The formulation of CINGAL allows for long-term relief of the symptoms of OA through lubrication and mechanical support from the viscosupplement component, enhanced by short-term pain relief provided by triamcinolone hexacetonide (TH) corticosteroid. Avoid injecting Cingal into the knees of patients who have skin diseases or infections in the area of the injection site. Use our clinic locator to find a specialist near you who can diagnose the cause of your knee pain and guide you through treatment options. The clinician may recommend a different dose based on the affected joint. Every patient’s experience is slightly different. The purpose of this study is to see if a single injection of Cingal into the knee provides safe relief of pain caused by osteoarthritis. CINGAL is designed for patients who demand quick results, want to remain active, prefer a single visit treatment, or are looking to delay reconstructive surgery. What are the side effects? CINGAL is provided as a single injection of 4.0 mL supplied in a 5.0 mL syringe. Strong safety profile in both an initial injection 1 as well as a repeat injection 2. It is a common, chronic, progressive musculoskeletal disorder. A single injection of a viscosupplement like Cingal® or Monovisc®, or three injections of Orthovisc® can help alleviate pain caused by osteoarthritis of the knee while increasing the flexibility and mobility of your knee. Patients may even experience other rare but serious side effects such as infection, … In a clinical study, CINGAL patients experienced statistically significant reduction in knee pain in the first week.5, In a CINGAL clinical study, significant knee pain relief was sustained through 6 months. Hyaluronan is a natural chemical found in the body. Cingal® combines two well-established treatments in a single injection, providing the benefits of both an approved corticosteroid and a proprietary high concentration of hyaluronic acid. Are there adverse reactions associated with Cingal®? How is CINGAL different than other treatment options? It’s now been six-plus months with the Cingal® injections in both knees. *Pain relief up to 6 months. Side effects include short-term pain flare-up, flushing of the face, thinning of skin or fat near the injection site, and risk of serious allergic reaction. For assessment of adverse reactions (ADRs), the following terms regarding frequency are used: 1. very common (≥1/10) 2. common (≥1/100 to <1/10) 3. uncommon (≥1/1,000 to <1/100) 4. rare (≥1/10,000 to 1