J Endocrinol Invest 2009;32(7):626-632. Galasko D. R., Peskind E., Clark C. M., Quinn J. F., Ringman J. M., Jicha G. A., Cotman C., Cottrell B., Montine T. J., Thomas R. G., Aisen P. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Hershey AD, Powers SW, Vockell AB, et al. Clinical experience of coenzyme Q10 to enhance intraoperative myocardial protection in coronary artery revascularization. J Neurol. View abstract. View abstract. Clin Exp Rhuematol. Forester BP, Harper DG, Georgakas J, Ravichandran C, Madurai N, Cohen BM. View abstract. First Conference of the International Coenzyme Q10 Association 2002; Wang, S. B., Weng, W. C., Lee, N. C., Hwu, W. L., Fan, P. C., and Lee, W. T. Mutation of mitochondrial DNA G13513A presenting with Leigh syndrome, Wolff-Parkinson-White syndrome and cardiomyopathy. Shojaei, M., Djalali, M., Khatami, M., Siassi, F., and Eshraghian, M. Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy. Vascul.Pharmacol. Galili, N., Sechman, E. V., Cerny, J., Mehdi, M., Mumtaz, M., Westervelt, P., Maguire, J., and Raza, A. View abstract. 5-8-2003;341(3):201-204. Lou Gehrig's disease (amyotrophic lateral sclerosis or ALS). Morre, D. M., Morre, D. J., Rehmus, W., and Kern, D. Supplementation with CoQ10 lowers age-related (ar) NOX levels in healthy subjects. 2015;73(3-4):205-11. doi: 10.1159/000377676. Clin Investig. Neurol.Sci 2009;30 Suppl 1:S121-S124. View abstract. Biofactors 1999;9:285-9. 1991;6. Antioxid.Redox.Signal. No side effects are getting known from taking coenzyme Q10. No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabolism and muscle fatigue. Int J Clin Pharmacol Ther.Toxicol 1990;28(3):123-126. View abstract. Shults CW, Beal MF, Fontaine D, et al. Heart damage caused by certain cancer drugs (anthracycline cardiotoxicity). Clin Ther. 1996;11(5):549-554. doi: 10.3390/nu10111697. Mizuno, M., Quistorff, B., Theorell, H., Theorell, M., and Chance, B. Roberts J. Coenzyme Q10 Side Effects. Res Commun.Chem Pathol.Pharmacol 1981;31(1):129-140. CoQ10 deficiency or lack of CoQ10 is most commonly associated with the damage of free radicals or oxidative stress. HIV/AIDS. View abstract. Doses of more than 300 mg may affect liver enzyme levels. 2016 Feb;24(2):637-46. Mischley, L. K., Allen, J., and Bradley, R. Coenzyme Q10 deficiency in patients with Parkinson's disease. Effect of coenzyme Q10 on biomarkers of oxidative stress and cardiac function in hemodialysis patients: the CoQ10 biomarker trial. Applying coenzyme Q10 to the gums is not effective for treating gum disease. In humans, toxicity is not usually observed, even with high doses of CoQ10. Application of ubiquinone ointment for intractable radiation ulcers: an expanded cytochrome C effect? Plasma coenzyme Q(10) in children and adolescents undergoing doxorubicin therapy. Dizziness 10. Mari D, Alleva R, Tomasetti M, and et al. View abstract. Cancer. 2006;21(3):253-255. J Neural Transm 1998;54:301-10. Patol.Fiziol.Eksp.Ter. 1985;124(4):21S-28S. View abstract. 2011;31(4):344-346. Coenzyme Q10 is a naturally occurring antioxidant that is often taken as a supplement to treat various illnesses. Isobe, C., Abe, T., and Terayama, Y. Coenzyme Q10 and exercise training in chronic heart failure. Rusciani, L., Proietti, I., Rusciani, A., Paradisi, A., Sbordoni, G., Alfano, C., Panunzi, S., De Gaetano, A., and Lippa, S. Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression. 2007;61(1):50-60. Lekoubou, A., Kouame-Assouan, A. E., Cho, T. H., Luaute, J., Nighoghossian, N., and Derex, L. Effect of long-term oral treatment with L-arginine and idebenone on the prevention of stroke-like episodes in an adult MELAS patient. Wahlqvist ML, Wattanapenpaiboon N, Savige GS, and et al. Curr Opin Neurol 1998;11:193-7. Makhija, N., Sendasgupta, C., Kiran, U., Lakshmy, R., Hote, M. P., Choudhary, S. K., Airan, B., and Abraham, R. The role of oral coenzyme Q10 in patients undergoing coronary artery bypass graft surgery. 2nd ed. These severe side effects may intimate that you should stop taking the supplements. Thibault A, Samid D, Tompkins AC, et al. Redox Rep 2018;23(1):136-45. doi: 10.1080/13510002.2018.1472924. Role of metabolic therapy in cardiovascular disease. 2015;10(12):e0141641. View abstract. Liver Int. Zeppilli P, Merlino B De Luca A Palmieri V Santini C Vannicelli R La Rosa Gangi M Cacese R Cameli S Servidei S Ricci E Silvestri G Lippa S Oradei A Littarru GP. Biofactors 2008;32:145-9. View abstract. View abstract. View abstract. Wilkinson EG, Arnold RM, Folkers K, and et al. View abstract. J Am Coll.Cardiol. View abstract. Neurology 3-14-2006;66(5):660-663. View abstract. View abstract. Coenzyme Q10. Eriksson JG, Forsen TJ, Mortensen SA, Rohde M. The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus. Adminstration of coenzyme Q10 to patients with essential hypertension. 2008;48(4-6):191-201. Medications for cancer (Chemotherapy) interacts with COENZYME Q10. In: Folkers, K. and Yamamura, Y. Biomedical and Clinical Aspects of Coenzyme Q10. Leuk.Res 2007;31(1):19-26. Mov Disord. Thompson PD, Clarkson P, Karas RH. First Conference of the International Coenzyme Q10 Association 2002; Gvozdjakova A, Kucharska J, Lepies P, and et al. Br Dent J 1995;178:209-13. Swelling (inflammation) of the heart (myocarditis). Amyotroph.Lateral.Scler.Other Motor Neuron Disord 2000;1(suppl 4):17-20. Feher, J., Kovacs, B., Kovacs, I., Schveoller, M., Papale, A., and Balacco, Gabrieli C. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. pregnancy, upcoming surgery, etc. 1996;157(4):511-512. Ferrer, M. D., Tauler, P., Sureda, A., Pujol, P., Drobnic, F., Tur, J. The efficacy and safety of coenzyme Q10 in Parkinson's disease: a meta-analysis of randomized controlled trials. Fumagalli, S., Fattirolli, F., Guarducci, L., Cellai, T., Baldasseroni, S., Tarantini, F., Di, Bari M., Masotti, G., and Marchionni, N. Coenzyme Q10 terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study. View abstract. Strong, M. J. and Pattee, G. L. Creatine and coenzyme Q10 in the treatment of ALS. 2008;9(13):2327-2337. View abstract. (Paris) 1991;147(6-7):542-548. Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Buyse, G. M., Goemans, N., van den Hauwe, M., Thijs, D., de Groot, I. J., Schara, U., Ceulemans, B., Meier, T., and Mertens, L. Idebenone as a novel, therapeutic approach for Duchenne muscular dystrophy: results from a 12 month, double-blind, randomized placebo-controlled trial. View abstract. Athletic performance. View abstract. Hidden disruptions in metabolic syndrome: drug-induced nutrient depletion as a pathway to accelerated pathophysiology of metabolic syndrome. Cardiovasc Ther. Klin Wochenschr 7-1-1988;66(13):583-590. View abstract. 2011;17(7):615-618. View abstract. Spindler M, Beal MF, Henchcliffe C. Coenzyme Q10 effects in neurodegenerative disease. View abstract. View abstract. Matthews, P. M., Ford, B., Dandurand, R. J., Eidelman, D. H., O'Connor, D., Sherwin, A., Karpati, G., Andermann, F., and Arnold, D. L. Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease. View abstract. Clin Biochem 2009;42:732-5. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. View abstract. Ubiquinol improves symptoms in children with autism. Reduced blood supply during heart or blood vessel surgery can deprive tissue of oxygen. View abstract. Nutr Metab Cardiovasc.Dis 2010;20(2):133-139. View abstract. J Neurol.Sci 4-15-2008;267(1-2):174-176. Mol.Aspects Med 1994;15 Suppl:s207-s212. View abstract. View abstract. View abstract. Fertil.Steril. View abstract. View abstract. View abstract. Judy WV, Willis RA, and Folkers K. Regression of prostate cancer and plasma specific antigens (PSA) in patients on treatment with COQ10. Klopstock, T., Yu-Wai-Man, P., Dimitriadis, K., Rouleau, J., Heck, S., Bailie, M., Atawan, A., Chattopadhyay, S., Schubert, M., Garip, A., Kernt, M., Petraki, D., Rummey, C., Leinonen, M., Metz, G., Griffiths, P. G., Meier, T., and Chinnery, P. F. A randomized placebo-controlled trial of idebenone in Leber's hereditary optic neuropathy. Rusciani, L., Proietti, I., Paradisi, A., Rusciani, A., Guerriero, G., Mammone, A., De Gaetano, A., and Lippa, S. Recombinant interferon alpha-2b and coenzyme Q10 as a postsurgical adjuvant therapy for melanoma: a 3-year trial with recombinant interferon-alpha and 5-year follow-up. Thromb Haemost 2002;87:1075-6. De Orthomoleculaire Koerier 1990;5(24):4-11. Effect of a nutritional supplement containing vitamin E, selenium, vitamin c and coenzyme Q10 on serum PSA in patients with hormonally untreated carcinoma of the prostate: a randomised placebo-controlled study. Current Therapeutic Research 1990;47(5):841-845. View abstract. 1997;95(1):11-20. View abstract. Br J Pharmacol 1998;124:1500-6. Tsubaki, K., Horiuchi, A., Kitani, T., Taniguchi, N., Masaoka, T., Shibata, H., Yonezawa, T., Tsubakio, T., Kawagoe, H., Shinohara, Y., and . Arch.Anim Nutr. Mizuno, K., Tanaka, M., Nozaki, S., Mizuma, H., Ataka, S., Tahara, T., Sugino, T., Shirai, T., Kajimoto, Y., Kuratsune, H., Kajimoto, O., and Watanabe, Y. Antifatigue effects of coenzyme Q10 during physical fatigue. Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency. Belaia, O. L., Kalmykova, V. I., Ivanova, L. A., and Kochergina, L. G. [Experience in coenzyme Q10 application in complex therapy of coronary heart disease with dyslipidemia]. Higher quality studies are needed to confirm these results. Early research suggests that taking coenzyme Q10 along with other antioxidants increases survival time by 40% in patients with terminal cancer. JAMA 2003;289:1681-90. Early research suggests that taking coenzyme Q10 by mouth might prevent the progression of a rare form of diabetes that is inherited from the mother. Biochem Biophys Acta 1995;1271:281-6. 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